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KMID : 0379120210490020243
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Korean Journal of Mycology
2021 Volume.49 No. 2 p.243 ~ p.248
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Production of an Anti-dementia Butyrylcholinesterase Inhibitor from Non-pathogenic Wild Yeast, Saccharomyces cerevisiae WJSL 0113
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Han Sang-Min
Park Seon-Jeong
Jang Ji-Eun
Lee Jong-Soo
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Abstract
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In this study, screening of potent non-pathogenic wild yeast with high anti-dementia butyrylcholinesterase (BChE) inhibitory activity and production condition of a BChE inhibitor were described. Among 36 non-pathogenic wild yeasts, Saccharomyces cerevisiae WJSL 0113 showed the highest BChE inhibitory activity of 85.2%. The specific BChE inhibitor was maximally produced when S. cerevisiae WJSL 0113 was cultured at 30℃ for 48 h in a yeast extract-peptone-dextrose medium.
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KEYWORD
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Anti-dementia, Butyrylcholinesterase inhibitor, Saccharomyces cerevisiae WJSL 0113, Wild yeast
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